Interaction between Yersinia pestis and the Host Immune System

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Host stress and immune responses during aerosol challenge of Brown Norway rats with Yersinia pestis

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Effects of Virulence and Fraction 1 antigens from Yersinia pestis on the human innate immune system

Yersinia pestis, the aetiological agent of plague, is responsible for a disease that has killed over 200 million people throughout history and generated three pandemics. This bacterium’s terrible success in causing disease is owed greatly to the virulence factors it expresses. Two of these factors are V antigen (LcrV) and F1 antigen (Caf1), both of which are two major antigens which the immune ...

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Despite the importance of pneumonic plague, little is known of the early pulmonary immune responses that occur following inhalation of Yersinia pestis. Therefore, we conducted studies to identify the early target cells for uptake of Y. pestis in the lungs following intratracheal or i.v. inoculation. Following intratracheal inoculation, Y. pestis was rapidly internalized primarily by a distincti...

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Yersinia pestis and plague.

Yersinia pestis is the aetiological agent of plague, a disease of humans that has potentially devastating consequences. Evidence indicates that Y. pestis evolved from Yersinia pseudotuberculosis, an enteric pathogen that normally causes a relatively mild disease. Although Y. pestis is considered to be an obligate pathogen, the lifestyle of this organism is surprisingly complex. The bacteria are...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 2008

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.01517-07